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Rapid action of glucocorticoids in mast cells

Bonicelli, Alice

Abstract:
Glucocorticoids (GCs) rapidly inhibit mast cells function, but the mechanism of action is still poorly understood. A knowledge of how GCs rapidly suppress allergy and inflammation mediated by these cells will aid in the development of new drugs with a better benefit-risk ratio. The aim of this research work was to study the rapid action of GCs in mast cells and investigate the involvement of the glucocorticoid receptor as a mediator of the rapid effects.


Zugehörige Institution(en) am KIT Institut für Toxikologie und Genetik (ITG)
Publikationstyp Hochschulschrift
Jahr 2016
Sprache Englisch
Identifikator DOI(KIT): 10.5445/IR/1000065373
URN: urn:nbn:de:swb:90-653731
KITopen ID: 1000065373
Verlag Karlsruhe
Umfang X, 87 S.
Abschlussart Dissertation
Fakultät Fakultät für Chemie und Biowissenschaften (CHEM-BIO)
Institut Institut für Toxikologie und Genetik (ITG)
Prüfungsdaten 16.12.2016
Referent/Betreuer Prof. A. Cato
Schlagworte Glucocorticoids, glucocorticoid receptor, primary mast cells, degranulation assay, MAPKs, polymer pen lithography (PPL)
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