Rapid action of glucocorticoids in mast cells

Glucocorticoids (GCs) rapidly inhibit mast cells function, but the mechanism of action is still poorly understood. A knowledge of how GCs rapidly suppress allergy and inflammation mediated by these cells will aid in the development of new drugs with a better benefit-risk ratio. The aim of this research work was to study the rapid action of GCs in mast cells and investigate the involvement of the glucocorticoid receptor as a mediator of the rapid effects.