Rapid action of glucocorticoids in mast cells
Abstract:
Glucocorticoids (GCs) rapidly inhibit mast cells function, but the mechanism of action is still poorly understood. A knowledge of how GCs rapidly suppress allergy and inflammation mediated by these cells will aid in the development of new drugs with a better benefit-risk ratio. The aim of this research work was to study the rapid action of GCs in mast cells and investigate the involvement of the glucocorticoid receptor as a mediator of the rapid effects.
| Zugehörige Institution(en) am KIT | Institut für Toxikologie und Genetik (ITG) |
| Publikationstyp | Hochschulschrift |
| Jahr | 2016 |
| Sprache | Englisch |
| Identifikator | URN: urn:nbn:de:swb:90-653731 KITopen ID: 1000065373 |
| HGF-Programm | 47.01.01; LK 01 |
| Verlag | Karlsruhe |
| Umfang | X, 87 S. |
| Abschlussart | Dissertation |
| Fakultät | Fakultät für Chemie und Biowissenschaften (CHEM-BIO) |
| Institut | Institut für Toxikologie und Genetik (ITG) |
| Prüfungsdaten | 16.12.2016 |
| Referent/Betreuer | Prof. A. Cato |
| Schlagworte | Glucocorticoids, glucocorticoid receptor, primary mast cells, degranulation assay, MAPKs, polymer pen lithography (PPL) |