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Research Update: Interfacing ultrasmall metal nanoclusters with biological systems

Shang, L.; Nienhaus, G. U.

Abstract (englisch):
Metal nanoclusters (NCs), a new type of nanomaterial with unique physicochemical properties, show great potential in many biomedical applications. Understanding their behavior in the complex biological environment is critical not only for designing highly efficient NC-based nanomedicines but also for elucidating the biological impact (e.g., toxicity) of these emerging nanomaterials. In this review, we give an overview of recent progress in exploring interactions of metal NCs with biological systems, including protein adsorption onto NCs, NC interactions with cells, and also the in vivo behavior of NCs. We also discuss the biological responses to the interactions, key parameters defining the interactions, and current challenges in the exploration of NCs in the complex biological environment.

Zugehörige Institution(en) am KIT Institut für Angewandte Physik (APH)
Institut für Nanotechnologie (INT)
Institut für Toxikologie und Genetik (ITG)
Publikationstyp Zeitschriftenaufsatz
Jahr 2017
Sprache Englisch
Identifikator DOI: 10.1063/1.4974514
ISSN: 2166-532X
KITopen ID: 1000065751
HGF-Programm 43.23.01; LK 01
Erschienen in APL materials
Band 5
Heft 5
Seiten 053101
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