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Theoretical Investigation of Kainate Receptor GluK2 and Channelrhodopsin-2: Structure and Mechanism

Guo, Yanan

Abstract:
This work focuses on the structures and mechanisms of functions of two different proteins: kainate receptor GluK2 and channelrhodopsin-2. They are able to activate neuron cells or transfer signals upon illumination, and thus, control and monitor neuron cell activities in living tissues. This technique is called optogenetics. The structure-function relationships of the proteins were investigated with multi-scale techniques, combining classic mechanical (MM) and quantum mechanical (QM) methods.


Zugehörige Institution(en) am KIT Institut für Physikalische Chemie (IPC)
Publikationstyp Hochschulschrift
Jahr 2017
Sprache Englisch
Identifikator DOI(KIT): 10.5445/IR/1000065871
URN: urn:nbn:de:swb:90-658717
KITopen ID: 1000065871
Verlag Karlsruhe
Umfang 168 S.
Abschlussart Dissertation
Fakultät Fakultät für Chemie und Biowissenschaften (CHEM-BIO)
Institut Institut für Physikalische Chemie (IPC)
Prüfungsdaten 10.02.2017
Referent/Betreuer Prof. M. Elstner
Lizenz CC BY-SA 3.0 DE: Creative Commons Namensnennung – Weitergabe unter gleichen Bedingungen 3.0 Deutschland
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