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Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus

Vries, R. P. de; Riley, R.; Wiebenga, A.; Aguilar-Osorio, G.; Amillis, S.; Uchima, C. A.; Anderluh, G.; Asadollahi, M.; Askin, M.; Barry, K.; Battaglia, E.; Bayram, O.; Benocci, T.; Braus-Stromeyer, S. A.; Caldana, C.; Cánovas, D.; Cerqueira, G. C.; Chen, F.; Chen, W.; Choi, C.; ... mehr

The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic contaminants of food, and an important genetic model. The genome sequences of eight aspergilli have already been explored to investigate aspects of fungal biology, raising questions about evolution and specialization within this genus.
We have generated genome sequences for ten novel, highly diverse Aspergillus species and compared these in detail to sister and more distant genera. Comparative studies of key aspects of fungal biology, including primary and secondary metabolism, stress response, biomass degradation, and signal transduction, revealed both conservation and diversity among the species. Observed genomic differences were validated with experimental studies. This revealed several highlights, such as the potential for sex in asexual species, organic acid production genes being a key feature of black aspergilli, alternative approaches for degrading plant biomass, and indications for the genetic basis of stress response. ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/1000067295
Veröffentlicht am 16.03.2018
DOI: 10.1186/s13059-017-1151-0
Zitationen: 138
Web of Science
Zitationen: 131
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Angewandte Biowissenschaften (IAB)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2017
Sprache Englisch
Identifikator ISSN: 1465-6906, 1465-6914, 1474-7596, 1474-760X
KITopen-ID: 1000067295
Erschienen in Genome biology
Band 18
Heft 1
Seiten 18:28
Schlagwörter Aspergillus, Genome sequencing, Comparative genomics, Fungal biology
Nachgewiesen in Web of Science
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