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Functional analysis of Protocadherin18a in zebrafish early development

Bösze, Bernadett


“It is not birth, marriage, or death, but gastrulation, which is truly the most important
time in your life.” (Lewis Wolpert, 1986).
Gastrulation is a pivotal phase of early embryonic development and leads to the
formation of the defining axial structure of all Chordates: the notochord. It is
essentially the result of major cell rearrangements and is driven by the coordinated
movement of mesodermal cells, often referred to as collective cell migration.
Cohesion is guided by various factors and stays connected via cadherin-based
junctions. In recent years, significant interest has been focused on the largest group
within the cadherins superfamily, the protocadherins. The presence of protocadherins
in the nervous system has commanded the most attention while little is known about
their role in cell-cell adhesions in early development.
In this work, I defined the role of Pcdh18a, a novel member of protocadherins in
zebrafish gastrulation. Pcdh18a is expressed in a confined cell group – termed the
notochord tip cells and exhibit strong connection to the trailing notochord progenitors.
At the molecular level, Pcdh18a mediates the recycling of E-cadherin and thereby
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DOI: 10.5445/IR/1000067480
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Toxikologie und Genetik (ITG)
Publikationstyp Hochschulschrift
Publikationsjahr 2016
Sprache Englisch
Identifikator urn:nbn:de:swb:90-674806
KITopen-ID: 1000067480
HGF-Programm 47.01.01 (POF III, LK 01) Biol.Netzwerke u.Synth.Regulat. ITG+ITC
Verlag Karlsruher Institut für Technologie (KIT)
Umfang XIII, 85 S.
Art der Arbeit Dissertation
Fakultät Fakultät für Chemie und Biowissenschaften (CHEM-BIO)
Institut Institut für Toxikologie und Genetik (ITG)
Prüfungsdatum 16.12.2016
Referent/Betreuer Scholpp, S.
KIT – Die Forschungsuniversität in der Helmholtz-Gemeinschaft
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