KIT | KIT-Bibliothek | Impressum

Zwitterion functionalized gold nanoclusters for multimodal near infrared fluorescence and photoacoustic imaging

Shen, D.; Henry, M.; Trouillet, V.; Comby-Zerbino, C.; Bertorelle, F.; Sancey, L.; Antoine, R.; Coll, J.-L.; Josserand, V.; Le Guével, X.

Abstract:
Gold nanoclusters (Au NCs) are an emerging type of theranostic agents combining therapeutic and imaging features with reduced toxicity. Au NCs stabilized by a zwitterion ligand with a fine control of the metal core size and the ligand coverage were synthesized by wet chemistry. Intense fluorescence signal is reported for the highest ligand coverage, whereas photoacoustic signal is stronger for the largest metal core. The best Au NC candidate with an average molecular weight of 17 kDa could be detected with high sensitivity on a 2D-near-infrared imaging instrument (limit of detection (LOD) = 2.3 μM
μM
) and by photoacoustic imaging. In vitro and in vivo experiments demonstrate an efficient cell uptake in U87 cell lines, a fast renal clearance (t 1/2α
t1/2α
= 6.5 ± 1.3 min), and a good correlation between near infrared fluorescence and photoacoustic measurements to follow the early uptake of Au NCs in liver.


Zugehörige Institution(en) am KIT Institut für Angewandte Materialien - Energiespeichersysteme (IAM-ESS)
Publikationstyp Zeitschriftenaufsatz
Jahr 2017
Sprache Englisch
Identifikator DOI: 10.1063/1.4977203
ISSN: 2166-532X
KITopen ID: 1000067839
HGF-Programm 47.02.08; LK 01
Erschienen in APL materials
Band 5
Heft 5
Seiten 053404
KIT – Die Forschungsuniversität in der Helmholtz-Gemeinschaft KITopen Landing Page