Core fuelling of DEMO tokamak fusion reactor is under investigation within the EUROfusion Work Package “Tritium, Fuelling and Vacuum”. An extensive analysis of fuelling requirements and technologies, suggests that pellet injection still represents, to date, the most realistic option. Modelling of both pellet penetration and fuel deposition profiles for different injection locations, assuming a specific plasma reference scenario and the ITER reference pellet mass (6 × 1021 atoms), indicates that: 1) Low Field Side (LFS) injection is inadequate; 2) Vertical injection may be effective only provided that pellets are injected at ∼ 10 km/s from a radial position ≤∼8 m; 3) effective core fuelling can be achieved launching pellets from the High Field Side (HFS) at ∼1 km/s. HFS injection was therefore selected as the reference scheme, though scenarios featuring less steep density and temperature gradients at the plasma edge could induce to reconsider vertical injection at speeds in the range of 4–5 km/s. To deliver intact pellets at 1 km/s from the HFS, the use of guide tubes with a bend radius ≥6 m is envisaged. The results of above simulations rely on the hypothesis that pellets are delivered at the plasma edge with the desired mass and speed. ... mehrHowever, mass erosion and fracturing of pellets inside the guide tube (severely limiting the transfer speed), as well as pressure build up and speed losses at relevant injection rates, might hamper the use of curved guide tubes. An additional innovative approach, aimed at identifying inboard straight “free flight” injection paths, to inject pellets from the HFS at significantly higher speeds, is proposed and discussed as a backup solution. Outboard high-speed injection is still being considered, instead, for JT-60SA.