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Magnetic field therapy in patients with cytostatics-induced polyneuropathy: A prospective randomized placebo-controlled phase-III study

Rick, Oliver; Hehn, Ulrike von; Mikus, Eberhard; Dertinger, Hermann 1; Geiger, Georg
1 Karlsruher Institut für Technologie (KIT)

Abstract:

No causal treatment for chemotherapy-induced peripheral neuropathy (CIPN) is known. Therefore, there is an urgent need to develop a therapy for CIPN. Only scarce clinical data are available concerning magnetic field therapy (MFT) in this context. We conducted a unicentric, randomized, double-blind, placebo-controlled phase-III trial of an MFT device versus placebo. In this study, we randomized 44 patients with CIPN to two treatment groups, where 21 patients were treated with MFT (Group 1) and 23 patients received placebo (Group 2). We evaluated the efficacy of MFT at baseline (T$_{1}$), after 3 weeks of study treatment (T$_{2}$), and after 3 months of study treatment (T$_{3}$). The primary endpoint was nerve conduction velocity (NCV), while secondary endpoints were the Common Toxicity Criteria (CTCAE) score and the Pain Detect End Score at T$_{3}$. Seventeen of the patients in Group 1 and 14 patients in Group 2 completed the respective study treatment. The primary endpoint, significant improvement of NCV at T$_{3}$, was achieved by MFT (P = 0.015), particularly for sensory neurotoxicity of the peroneal nerve. Also, in respect to the secondary endpoints, significant improvement (P = 0.04) was achieved in terms of the patients’ subjectively perceived neurotoxicity (CTCAE score), but not of neuropathic pain (P = 0.11). ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000071073
Veröffentlicht am 20.04.2018
Originalveröffentlichung
DOI: 10.1002/bem.22005
Scopus
Zitationen: 17
Web of Science
Zitationen: 12
Dimensions
Zitationen: 19
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische Grenzflächen (IBG)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2017
Sprache Englisch
Identifikator ISSN: 0197-8462, 1521-186X
urn:nbn:de:swb:90-710734
KITopen-ID: 1000071073
HGF-Programm 47.02.01 (POF III, LK 01) Zellpopul.auf Biofunk.Oberflächen IBG-1
Erschienen in Bioelectromagnetics
Verlag Wiley-Liss
Band 38
Heft 2
Seiten 85-94
Vorab online veröffentlicht am 22.09.2016
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Scopus
Web of Science
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