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Cognitive and affective trait and state factors influencing the long-term symptom course in remitted depressed patients

Timm, Christina; Ubl, Bettina; Zamoscik, Vera; Ebner-Priemer, Ulrich; Reinhard, Iris; Huffziger, Silke; Kirsch, Peter; Kuehner, Christine

Background: Major depressive disorder (MDD) is characterized by a high risk for relapses and chronic
developments. Clinical characteristics such as residual symptoms have been shown to negatively
affect the long-term course of MDD. However, it is unclear so far how trait repetitive
negative thinking (RNT) as well as cognitive and affective momentary states, the latter experienced
during daily-life, affect the long-term course of MDD.
Method: We followed up 57 remitted depressed (rMDD) individuals six (T2) and 36 (T3) months after
baseline. Clinical outcomes were time to relapse, time spent with significant symptoms as a
marker of chronicity, and levels of depressive symptoms at T2 and T3. Predictors assessed
at baseline included residual symptoms and trait RNT. Furthermore, momentary daily life
affect and momentary rumination, and their variation over the day were assessed at baseline
using ambulatory assessment (AA).
Results: In multiple models, residual symptoms and instability of daily-life affect at baseline independently
predicted a faster time to relapse, while chronicity was significantly predicted by trait
RNT. Multilevel models revealed that depressive symptom levels during follow-up were predicted
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Volltext §
DOI: 10.5445/IR/1000071165
DOI: 10.1371/journal.pone.0178759
Zitationen: 9
Web of Science
Zitationen: 12
Zitationen: 11
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2017
Sprache Englisch
Identifikator ISSN: 1932-6203
KITopen-ID: 1000071165
Erschienen in PLoS one
Verlag Public Library of Science (PLoS)
Band 12
Heft 6
Seiten Art. Nr. e0178759
Nachgewiesen in Dimensions
Web of Science
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