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Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy

Janz, Philipp; Schwaderlapp, Niels; Heining, Katharina; Häussler, Ute; Korvink, Jan G; Elverfeldt, Dominik von; Hennig, Jürgen; Egert, Ulrich; LeVan, Pierre; Haas, Carola A

Mesial temporal lobe epilepsy (mTLE) is the most common focal epilepsy in adults and is often refractory to medication. So far, resection of the epileptogenic focus represents the only curative therapy. It is unknown whether pathological processes preceding epilepsy onset are indicators of later disease severity. Using longitudinal multi-modal MRI, we monitored hippocampal injury and tissue reorganization during epileptogenesis in a mouse mTLE model. The prognostic value of MRI biomarkers was assessed by retrospective correlations with pathological hallmarks Here, we show for the first time that the extent of early hippocampal neurodegeneration and progressive microstructural changes in the dentate gyrus translate to the severity of hippocampal sclerosis and seizure burden in chronic epilepsy. Moreover, we demonstrate that structural MRI biomarkers reflect the extent of sclerosis in human hippocampi. Our findings may allow an early prognosis of disease severity in mTLE before its first clinical manifestations, thus expanding the therapeutic window.

Zugehörige Institution(en) am KIT Institut für Mikrostrukturtechnik (IMT)
Publikationstyp Zeitschriftenaufsatz
Jahr 2017
Sprache Englisch
Identifikator DOI: 10.7554/eLife.25742
ISSN: 2050-084X
URN: urn:nbn:de:swb:90-724017
KITopen ID: 1000072401
HGF-Programm 47.01.03; LK 01
Erschienen in eLife
Band 6
Seiten Art. Nr. e25742
Lizenz CC BY 4.0: Creative Commons Namensnennung 4.0 International
URLs Link
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