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Polymer Structures on Surface Acoustic Wave Biosensors

Ritter, F.; Hedrich, J.; Deck, M.; Ludwig, F.; Shakirov, D.; Rapp, B. E.; Länge, K.

Abstract:

The influence of surface structuring on surface acoustic wave (SAW) biosensor signals has been investigated. Polymer structures on the sensor surfaces were applied by lithography or by self-assembling of polystyrene microparticles. In first experiments, structured and unstructured sensors led to similar results in a model affinity assay using streptavidin and biotinylated protein. On the other hand, structuring had a strong effect on SAW sensor signals obtained by protein adsorption on parylene C coated sensors. Depending on the protein, both decreased (albumin, streptavidin) and increased (fibrinogen) signals were observed with structured SAW sensors. Particularly the latter could contribute to facilitated blood analysis in the future.


Verlagsausgabe §
DOI: 10.5445/IR/1000072777
Originalveröffentlichung
DOI: 10.1016/j.protcy.2017.04.017
Dimensions
Zitationen: 9
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Mikrostrukturtechnik (IMT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2017
Sprache Englisch
Identifikator ISSN: 2212-0173
urn:nbn:de:swb:90-727770
KITopen-ID: 1000072777
HGF-Programm 47.02.07 (POF III, LK 01) Zellpopul.auf Biofunk.Oberflächen IMT
Erschienen in Procedia Technology
Verlag Elsevier
Band 27
Seiten 35–36
Bemerkung zur Veröffentlichung 26th Anniversary World Congress on Biosensors, Göteborg, S, May 25-27, 2016
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