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URN: urn:nbn:de:swb:90-730687
Originalveröffentlichung
DOI: 10.1016/j.scr.2017.07.011

Murine transgenic embryonic stem cell lines for the investigation of sinoatrial node-related molecular pathways [in press]

Schmitteckert, Stefanie; Griesbeck, Anne; Sumer, Simon; Jauch, Anna; Rolletschek, Alexandra; Niesler, Beate; Rappold, Gudrun A.; Hoffmann, Sandra

Abstract:
The elucidation of molecular mechanisms that restrict the potential of pluripotent stem cells and promote cardiac lineage differentiation is of crucial relevance, since embryonic stem cells (ESCs) hold great potential for cell based heart therapies. The homeodomain transcription factor Shox2 is essential for the development and proper function of the native cardiac pacemaker, the sinoatrial node. This prompted us to develop a cardiac differentiation model using ESC lines isolated from blastocysts of Shox2-deficient mice. The established cell model provides a fundamental basis for the investigation of molecular pathways under physiological and pathophysiological conditions for evaluating novel therapeutic approaches.


Zugehörige Institution(en) am KIT Institut für Biologische Grenzflächen (IBG)
Publikationstyp Zeitschriftenaufsatz
Jahr 2017
Sprache Englisch
Identifikator ISSN: 1873-5061, 1876-7753
URN: urn:nbn:de:swb:90-730687
KITopen ID: 1000073068
Erschienen in Stem cell research
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