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Abnormal N400 Semantic Priming Effect May Reflect Psychopathological Processes in Schizophrenia : A Twin Study

Sharma, Anuradha; Sauer, Heinrich; Hill, Holger; Kaufmann, Claudia; Bender, Stephan; Weisbrod, Matthias

Abstract:
Objective: Activation of semantic networks is indexed by the N400 effect. We used a twin study design to investigate whether N400 effect abnormalities reflect genetic/trait liability or are related to psychopathological processes in schizophrenia. Methods. We employed robust linear regression to compare N400 and behavioral priming effects across 36 monozygotic twin pairs (6 pairs concordant for schizophrenia/schizoaffective disorder, 11 discordant pairs, and 19 healthy control pairs) performing a lexical decision task.Moreover, we examined the correlation between Brief Psychiatric Rating Scale (BPRS) score and the N400 effect and the influence of medication status on this effect. Results. Regression yielded a significant main effect of group on the N400 effect only in the direct priming condition (𝑝 = 0.003). Indirect condition and behavioral priming effect showed no significant effect of group. Planned contrasts with the control group as a reference group revealed that affected concordant twins had significantly reduced N400 effect compared to controls, and discordant affected twins had a statistical trend for reduced N400 effect compared to controls.The unaffected twins did not differ significantly from the controls.There was a trend for correlation between reduced N400 effect and higher BPRS scores, and the N400 effect did not differ significantly between medicated and unmedicated patients. ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/1000076951
Veröffentlicht am 28.11.2017
Coverbild
Zugehörige Institution(en) am KIT Institut fĂŒr Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Jahr 2017
Sprache Englisch
Identifikator ISSN: 2090-2085, 2090-2093
urn:nbn:de:swb:90-769513
KITopen-ID: 1000076951
Erschienen in Schizophrenia research and treatment
Band 2017
Seiten Art.Nr. 7163198
Nachgewiesen in Scopus
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