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The corneal subbasal nerve plexus and thickness of the retinal layers in pediatric type 1 diabetes and matched controls

Götze, Aline; Keyserlingk, Sophie von; Peschel, Sabine; Jacoby, Ulrike; Schreiver, Corinna; Köhler, Bernd 1; Allgeier, Stephan ORCID iD icon 1; Winter, Karsten; Röhlig, Martin; Jünemann, Anselm; Guthoff, Rainer; Stachs, Oliver; Fischer, Dagmar-C.
1 Karlsruher Institut für Technologie (KIT)


Optical coherence tomography (OCT) of the retina and corneal confocal laser scanning microscopy (CLSM) of the subbasal nerve plexus (SBP) are noninvasive techniques for quantification of the ocular neurodegenerative changes in individuals with type 1 diabetes mellitus (T1DM). In adult T1DM patients these changes are hardly related to T1DM only. Instead, ageing and/or lifestyle associated comorbidities have to be considered as putative confounding variables. Therefore, we investigated pediatric T1DM patients (n = 28; 14.2 ± 2.51 y; duration of disease: 5.39 ± 4.16 y) without clinical signs of diabetic retina disease, neuropathy, vasculopathy or nephropathy and compared our findings with those obtained in healthy controls (n = 46; 14.8 ± 1.89 y). The SBP was characterized by the averaged length, thickness, and tortuosity of nerve fibers as well as the number of branching and connecting points. OCT was used to determine the total thickness of the retina (ALL) and the thickness of each retinal layer. Both methods revealed signs of early neurodegenerative changes, e.g. thinning of distinct retinal layers at the pericentral ring and shortening of corneal nerve fibers that are already present in pediatric T1DM patients. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000078477
Veröffentlicht am 08.01.2018
DOI: 10.1038/s41598-017-18284-z
Zitationen: 22
Web of Science
Zitationen: 22
Zitationen: 38
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Automation und angewandte Informatik (IAI)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2018
Sprache Englisch
Identifikator ISSN: 2045-2322
KITopen-ID: 1000078477
HGF-Programm 43.23.02 (POF III, LK 01) X-Ray Optics
Erschienen in Scientific reports
Verlag Nature Research
Band 8
Heft 1
Seiten Art.Nr. 14
Projektinformation DFG, DFG EIN, KO 5003/1-1
Vorab online veröffentlicht am 08.01.2018
Nachgewiesen in Dimensions
Web of Science
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