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DOI: 10.5445/IR/1000078477
DOI: 10.1038/s41598-017-18284-z

The corneal subbasal nerve plexus and thickness of the retinal layers in pediatric type 1 diabetes and matched controls

Götze, Aline; Keyserlingk, Sophie von; Peschel, Sabine; Jacoby, Ulrike; Schreiver, Corinna; Köhler, Bernd; Allgeier, Stephan; Winter, Karsten; Röhlig, Martin; Jünemann, Anselm; Guthoff, Rainer; Stachs, Oliver; Fischer, Dagmar-C.

Optical coherence tomography (OCT) of the retina and corneal confocal laser scanning microscopy (CLSM) of the subbasal nerve plexus (SBP) are noninvasive techniques for quantification of the ocular neurodegenerative changes in individuals with type 1 diabetes mellitus (T1DM). In adult T1DM patients these changes are hardly related to T1DM only. Instead, ageing and/or lifestyle associated comorbidities have to be considered as putative confounding variables. Therefore, we investigated pediatric T1DM patients (n = 28; 14.2 ± 2.51 y; duration of disease: 5.39 ± 4.16 y) without clinical signs of diabetic retina disease, neuropathy, vasculopathy or nephropathy and compared our findings with those obtained in healthy controls (n = 46; 14.8 ± 1.89 y). The SBP was characterized by the averaged length, thickness, and tortuosity of nerve fibers as well as the number of branching and connecting points. OCT was used to determine the total thickness of the retina (ALL) and the thickness of each retinal layer. Both methods revealed signs of early neurodegenerative changes, e.g. thinning of distinct retinal layers at the pericentral ring and short ... mehr

Zugehörige Institution(en) am KIT Institut für Automation und angewandte Informatik (IAI)
Publikationstyp Zeitschriftenaufsatz
Jahr 2018
Sprache Englisch
Identifikator ISSN: 2045-2322
URN: urn:nbn:de:swb:90-784773
KITopen ID: 1000078477
HGF-Programm 43.23.02; LK 01
Erschienen in Scientific reports
Band 8
Heft 1
Seiten Art.Nr. 14
Vorab online veröffentlicht am 08.01.2018
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