Bio-fuels of the 2nd generation constitute a key approach to tackle both Greenhouse Gas (GHG) and air quality challenges associated with combustion emissions of the transport sector. Since these fuels are obtained of residual materials of the agricultural industry, well-totank CO2 emissions can be significantly lowered by a closed-cycle of formation and absorption of CO2. Furthermore, studies of bio-fuels have shown reduced formation of particulate matter on account of the fuels’ high oxygen content therefore addressing air quality issues. However, due to the high oxygen content and other physical parameters these fuels are expected to exhibit different ignition behaviour. Moreover, the question is whether there is a positive superimposition of the fuels ignition behaviour with the benefits of an alternative ignition system, such as a corona ignition. To shed light on these questions two oxygenic compounds, oxymethylene ether-1 (OME1) and dimethyl carbonate (DMC) have been studied with respect to OH* emission throughout ignition and onset of flame-front propagation in a combustion chamber with a large optical access via a quartz win ... mehrdow. OH* measurements have been recorded via a highspeed optical camera (5 kHz) coupled with 308 nm optical filter and image intensifier. Sealing material swelling tests have yielded a perfluoroelastomer (FFKM 72) as an ideal, cost-efficient material regardless of the applied fuel. Comparative measurements with both ignition systems for combustion of gasoline as well as moderate blend admixtures of OME1 and DMC have demonstrated the superior ignition stability with likewise implications on flame-kernel development for the corona ignition. Furthermore a strong influence of the mode of discharge on OH* formation rates was observed especially for the oxygenic blends. Finally, for admixture variations of both oxygenates, an increased OH* level was shown during discharge thereby proving the hypothesis of a positive superimposition of oxygenic fuel and corona ignition system.