KIT | KIT-Bibliothek | Impressum
Open Access Logo
DOI: 10.5445/IR/1000082513
Veröffentlicht am 02.05.2018

Wide-field corneal subbasal nerve plexus mosaics in age-controlled healthy and type 2 diabetes populations

Lagali, Neil S.; Allgeier, Stephan; Guimarães, Pedro; Badian, Reza A.; Ruggeri, Alfredo; Köhler, Bernd; Utheim, Tor Paaske; Peebo, Beatrice; Peterson, Magnus; Dahlin, Lars B.; Rolandsson, Olov

A dense nerve plexus in the clear outer window of the eye, the cornea, can be imaged in vivo to enable non-invasive monitoring of peripheral nerve degeneration in diabetes. However, a limited field of view of corneal nerves, operator-dependent image quality, and subjective image sampling methods have led to difficulty in establishing robust diagnostic measures relating to the progression of diabetes and its complications. Here, we use machine-based algorithms to provide wide-area mosaics of the cornea’s subbasal nerve plexus (SBP) also accounting for depth (axial) fluctuation of the plexus. Degradation of the SBP with age has been mitigated as a confounding factor by providing a dataset comprising healthy and type 2 diabetes subjects of the same age. To maximize reuse, the dataset includes bilateral eye data, associated clinical parameters, and machine-generated SBP nerve density values obtained through automatic segmentation and nerve tracing algorithms. The dataset can be used to examine nerve degradation patterns to develop tools to non-invasively monitor diabetes progression while avoiding narrow-field imaging and image selectio ... mehr

Zugehörige Institution(en) am KIT Institut für Automation und angewandte Informatik (IAI)
Publikationstyp Zeitschriftenaufsatz
Jahr 2018
Sprache Englisch
Identifikator ISSN: 2052-4463
URN: urn:nbn:de:swb:90-825132
KITopen ID: 1000082513
HGF-Programm 43.23.02; LK 01
Erschienen in Scientific data
Band 5
Seiten Art.Nr. 180075
Vorab online veröffentlicht am 24.04.2018
KIT – Die Forschungsuniversität in der Helmholtz-Gemeinschaft KITopen Landing Page