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Characterization of Nanoparticle Batch-To-Batch Variability

Mülhopt, Sonja; Diabaté, Silvia; Dilger, Marco; Adelhelm, Christel; Anderlohr, Christopher; Bergfeldt, Thomas; Gómez de la Torre, Johan; Jiang, Yunhong; Valsami-Jones, Eugenia; Langevin, Dominique; Lynch, Iseult; Mahon, Eugene; Nelissen, Inge; Piella, Jordi; Puntes, Victor; Ray, Sikha; Schneider, Reinhard; Wilkins, Terry; Weiss, Carsten; Paur, Hanns-Rudolf

Abstract:
A central challenge for the safe design of nanomaterials (NMs) is the inherent variability of NM properties, both as produced and as they interact with and evolve in, their surroundings. This has led to uncertainty in the literature regarding whether the biological and toxicological effects reported for NMs are related to specific NM properties themselves, or rather to the presence of impurities or physical effects such as agglomeration of particles. Thus, there is a strong need for systematic evaluation of the synthesis and processing parameters that lead to potential variability of different NM batches and the reproducible production of commonly utilized NMs. The work described here represents over three years of effort across 14 European laboratories to assess the reproducibility of nanoparticle properties produced by the same and modified synthesis routes for four of the OECD priority NMs (silica dioxide, zinc oxide, cerium dioxide and titanium dioxide) as well as amine-modified polystyrene NMs, which are frequently employed as positive controls for nanotoxicity studies. For 46 different batches of the selected NMs, all physicoc ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/1000082825
Veröffentlicht am 18.05.2018
Originalveröffentlichung
DOI: 10.3390/nano8050311
Scopus
Zitationen: 2
Web of Science
Zitationen: 2
Zugehörige Institution(en) am KIT Institut für Toxikologie und Genetik (ITG)
Institut für Angewandte Materialien - Angewandte Werkstoffphysik (IAM-AWP)
Institut für Technische Chemie (ITC)
Publikationstyp Zeitschriftenaufsatz
Jahr 2018
Sprache Englisch
Identifikator ISSN: 2079-4991
urn:nbn:de:swb:90-828250
KITopen-ID: 1000082825
HGF-Programm 47.01.01 (POF III, LK 01)
Erschienen in Nanomaterials
Band 8
Heft 5
Seiten Article: 311
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
Vorab online veröffentlicht am 08.05.2018
Schlagworte nanosafety; particle size; impurities; reactive oxygen species; BTA
Nachgewiesen in Web of Science
Scopus
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