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Self-reporting and refoldable profluorescent single-chain nanoparticles

Fischer, Tobias S.; Spann, Sebastian; An, Qi; Luy, Burkhard; Tsotsalas, Manuel; Blinco, James P.; Mutlu, Hatice; Barner-Kowollik, Christopher

We pioneer the formation of self-reporting and refoldable profluorescent single-chain nanoparticles (SCNPs) via the light-induced reaction (λmax = 320 nm) of nitroxide radicals with a photo-active crosslinker. Whereas the tethered nitroxide moiety in these polymers fully quenches the luminescence (i.e. fluorescence) of the aromatic backbone, nitroxide trapping of a transient C-radical leads to the corresponding closed shell alkoxyamine thereby restoring luminescence of the folded SCNP. Hence, the polymer in the folded state is capable of emitting light, while in the non-folded state the luminescence is silenced. Under oxidative conditions the initially folded SCNPs unfold, resulting in luminescence switch-off and the reestablishment of the initial precursor polymer. Critically, we show that the luminescence can be repeatedly silenced and reactivated. Importantly, the self-reporting character of the SCNPs was followed by size-exclusion chromatography (SEC), dynamic light scattering (DLS), fluorescence, electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR) and diffusion ordered NMR spectroscopy (DOSY).

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Verlagsausgabe §
DOI: 10.5445/IR/1000083384
Veröffentlicht am 12.06.2018
DOI: 10.1039/C8SC01009A
Zitationen: 5
Web of Science
Zitationen: 4
Zugehörige Institution(en) am KIT Institut für Technische Chemie und Polymerchemie (ITCP)
Institut für Organische Chemie (IOC)
Institut für Funktionelle Grenzflächen (IFG)
Institut für Biologische Grenzflächen (IBG)
Publikationstyp Zeitschriftenaufsatz
Jahr 2018
Sprache Englisch
Identifikator ISSN: 2041-6520, 2041-6539
KITopen-ID: 1000083384
HGF-Programm 47.02.03 (POF III, LK 01)
Erschienen in Chemical science
Band 9
Heft 20
Seiten 4696–4702
Vorab online veröffentlicht am 30.04.2018
Nachgewiesen in Web of Science
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