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Current perspectives on opisthorchiasis control and cholangiocarcinoma detection in southeast asia (Review)

Khuntikeo, N.; Titapun, A.; Loilome, W.; Yongvanit, P.; Thinkhamrop, B.; Chamadol, N.; Boonmars, T.; Nethanomsak, T.; Andrews, R. H.; Petney, T. N.; Sithithaworn, P.

Similar to bile duct cancer or cholangiocarcinoma (CCA) in the western world, opisthorchiasis-associated CCA in Southeast Asia is an aggressive cancer with high mortality rates. It is known to cause a significant health burden in the opisthorchiasis region in Thailand and possibly throughout mainland Southeast. To reduce this health burden, a comprehensive prevention and control program for opisthorchiasis, as well as CCA, is required. In this review, our aim is to provide a brief update of the current situation regarding the natural history of opisthorchiasis and health burden of CCA in Southeast Asia. A comprehensive approach to tackling these issues being implemented in Thailand under the "Cholangiocarcinoma Screening and Care Program" is described. This comprehensive program consists of a three stage prevention and patient care program. The primary prevention component involves opisthorchiasis screening using a new and sensitive urine assay. The secondary prevention component involves screening for CCA and periductal fibrosis, with suspected CCA patients following the protocol for confirmation and appropriate treatment. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000085271
Veröffentlicht am 23.08.2018
DOI: 10.3389/fmed.2018.00117
Zitationen: 18
Zitationen: 24
Cover der Publikation
Zugehörige Institution(en) am KIT Zoologisches Institut (ZOO)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2018
Sprache Englisch
Identifikator ISSN: 2296-858X
KITopen-ID: 1000085271
Erschienen in Frontiers in medicine
Verlag Frontiers Media
Band 5
Heft APR
Seiten Art. Nr.: 117
Vorab online veröffentlicht am 30.04.2018
Nachgewiesen in Web of Science
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