For the successful implementation of Manufacturing Systems 4.0 (MS4.0) in medium-sized companies, a structured introduction process is required. Main objective of this process is the analysis and evaluation of MS4.0 methods in order to select those that suit best for each company. The foundation of this process is a structure model to classify and describe MS4.0 methods. A subsequent analysis of interactions among the methods supports the identification and evaluation of effective implementation strategies. Thereby, a model based on system dynamics is applied. Based on the results, the methods are strategically and financially evaluated to select the MS4.0 methods suited for implementation. Finally, a method roadmap can be derived to support management for the strategic decisions in regards of MS4.0 methods.