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A computational framework to benchmark basket catheter guided ablation in atrial fibrillation

Alessandrini, M.; Valinoti, M.; Unger, L.; Oesterlein, T.; Dössel, O.; Corsi, C.; Loewe, A.; Severi, S.

Catheter ablation is a curative therapeutic approach for atrial fibrillation (AF). Ablation of rotational sources based on basket catheter measurements has been proposed as a promising approach in patients with persistent AF to complement pulmonary vein isolation. However, clinically reported success rates are equivocal calling for a mechanistic investigation under controlled conditions. We present a computational framework to benchmark ablation strategies considering the whole cycle from excitation propagation to electrogram acquisition and processing to virtual therapy. Fibrillation was induced in a patient-specific 3D volumetric model of the left atrium, which was homogeneously remodeled to sustain reentry. The resulting extracellular potential field was sampled using models of grid catheters as well as realistically deformed basket catheters considering the specific atrial anatomy. The virtual electrograms were processed to compute phase singularity density maps to target rotor tips with up to three circular ablations. Stable rotors were successfully induced in different regions of the homogeneously remodeled atrium showing that rotors are not constrained to unique anatomical structures or locations. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000087607
Veröffentlicht am 04.01.2019
DOI: 10.3389/fphys.2018.01251
Zitationen: 10
Zitationen: 12
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biomedizinische Technik (IBT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2018
Sprache Englisch
Identifikator ISSN: 1664-042X
KITopen-ID: 1000087607
Erschienen in Frontiers in physiology
Verlag Frontiers Media
Band 9
Seiten Article: 1251
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
Schlagwörter atrial fibrillation; ablation; basket catheter; computational modeling; rotor
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