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Research on the methods for the mass production of multi-scale organs-on-chips

Lantada, A. D.; Pfleging, W. ORCID iD icon 1,2; Besser, H. 1,2; Guttmann, M. 2,3; Wissmann, M. 2,3; Plewa, K. 2,4; Smyrek, P. 1,2; Piotter, V. 2,4; García-Ruíz, J. P.
1 Institut für Angewandte Materialien – Angewandte Werkstoffphysik (IAM-AWP), Karlsruher Institut für Technologie (KIT)
2 Karlsruhe Nano Micro Facility (KNMF), Karlsruher Institut für Technologie (KIT)
3 Institut für Mikrostrukturtechnik (IMT), Karlsruher Institut für Technologie (KIT)
4 Institut für Technik der Informationsverarbeitung (ITIV), Karlsruher Institut für Technologie (KIT)


The success of labs- and organs-on-chips as transformative technologies in the biomedical arena relies on our capacity of solving some current challenges related to their design, modeling, manufacturability, and usability. Among present needs for the industrial scalability and impact promotion of these bio-devices, their sustainable mass production constitutes a breakthrough for reaching the desired level of repeatability in systematic testing procedures based on labs- and organs-on-chips. The use of adequate biomaterials for cell-culture processes and the achievement of the multi-scale features required, for in vitro modeling the physiological interactions among cells, tissues, and organoids, which prove to be demanding requirements in terms of production. This study presents an innovative synergistic combination of technologies, including: laser stereolithography, laser material processing on micro-scale, electroforming, and micro-injection molding, which enables the rapid creation of multi-scale mold cavities for the industrial production of labs- and organs-on-chips using thermoplastics apt for in vitro testing. The procedure is validated by the design, rapid prototyping, mass production, and preliminary testing with human mesenchymal stem cells of a conceptual multi-organ-on-chip platform, which is conceived for future studies linked to modeling cell-to-cell communication, understanding cell-material interactions, and studying metastatic processes.

Verlagsausgabe §
DOI: 10.5445/IR/1000087867
Veröffentlicht am 28.11.2018
DOI: 10.3390/polym10111238
Zitationen: 16
Web of Science
Zitationen: 10
Zitationen: 17
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Angewandte Materialien – Angewandte Werkstoffphysik (IAM-AWP)
Institut für Angewandte Materialien - Werkstoffprozesstechnik (IAM-WPT)
Institut für Mikrostrukturtechnik (IMT)
Karlsruhe Nano Micro Facility (KNMF)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2018
Sprache Englisch
Identifikator ISSN: 2073-4360
KITopen-ID: 1000087867
HGF-Programm 49.01.02 (POF III, LK 02) IMT-KNMF Structuring Lab
Erschienen in Polymers
Verlag MDPI
Band 10
Heft 11
Seiten Art. Nr.: 1238
Schlagwörter organs-on-chips, labs-on-chips, additive manufacturing, laser materials processing, electroforming, mold fabrication, micro-injection molding, mass production, biomedical microdevices,, Proposal-ID: 2017-018-019450 (KNMF-LMP, - IM, -HE)
Nachgewiesen in Web of Science
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