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Verlagsausgabe
DOI: 10.5445/IR/1000087867
Veröffentlicht am 28.11.2018

Research on the methods for the mass production of multi-scale organs-on-chips

Lantada, A. D.; Pfleging, W.; Besser, H.; Guttmann, M.; Wissmann, M.; Plewa, K.; Smyrek, P.; Piotter, V.; García-Ruíz, J. P.

Abstract:
The success of labs- and organs-on-chips as transformative technologies in the biomedical arena relies on our capacity of solving some current challenges related to their design, modeling, manufacturability, and usability. Among present needs for the industrial scalability and impact promotion of these bio-devices, their sustainable mass production constitutes a breakthrough for reaching the desired level of repeatability in systematic testing procedures based on labs- and organs-on-chips. The use of adequate biomaterials for cell-culture processes and the achievement of the multi-scale features required, for in vitro modeling the physiological interactions among cells, tissues, and organoids, which prove to be demanding requirements in terms of production. This study presents an innovative synergistic combination of technologies, including: laser stereolithography, laser material processing on micro-scale, electroforming, and micro-injection molding, which enables the rapid creation of multi-scale mold cavities for the industrial production of labs- and organs-on-chips using thermoplastics apt for in vitro testing. The procedure is ... mehr


Zugehörige Institution(en) am KIT Institut für Angewandte Materialien - Angewandte Werkstoffphysik (IAM-AWP)
Institut für Mikrostrukturtechnik (IMT)
Karlsruhe Nano Micro Facility (KNMF)
Institut für Angewandte Materialien - Werkstoffprozesstechnik (IAM-WPT)
Publikationstyp Zeitschriftenaufsatz
Jahr 2018
Sprache Englisch
Identifikator ISSN: 2073-4360
URN: urn:nbn:de:swb:90-878677
KITopen ID: 1000087867
HGF-Programm 49.01.02; LK 02
Erschienen in Polymers
Band 10
Heft 11
Seiten Art. Nr.: 1238
Schlagworte organs-on-chips, labs-on-chips, additive manufacturing, laser materials processing, electroforming, mold fabrication, micro-injection molding, mass production, biomedical microdevices
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