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High-density mapping reveals short-term reversibility of atrial ablation lesions

Huhn, O. 1; Pollnow, S. 1; Unger, L. 1; Dössel, O. 1; Oesterlein, T. 1; Luik, A.; Schmitt, C.
1 Institut für Biomedizinische Technik (IBT), Karlsruher Institut für Technologie (KIT)


Cardiac arrhythmias such as atrial fibrillation occur frequently in industrialized countries. Radiofrequency ablation (RFA) is a standard treatment if drug therapy fails. This minimally invasive surgery aims at stabilizing the heart rhythm on a permanent basis. However, the procedure commonly needs to be repeated because of the high recurrence rate of arrhythmias. Non-transmural lesions as well as gaps within linear lesions are among the main problems during the RFA. The assessment of lesion formation is not adequate in state of the art procedures. Therefore, the aim of this study is to investigate the short-term reversibility of lesions using human electrograms recorded by a high-density mapping system during an electrophysiological study (EPS). A predefined measurement protocol was executed during the EPS in order to create three ablation points in the left atrium. Subsequently, after preprocessing the recorded signals, electrogram (EGM) paths were formed along the endocardial surface of the atrium. By analyzing changes of peak to peak amplitudes of unipolar EGMs before and after ablation, it was possible to distinguish lesion area and healthy myocardium. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000090646
Veröffentlicht am 08.02.2019
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biomedizinische Technik (IBT)
Universität Karlsruhe (TH) – Interfakultative Einrichtungen (Interfakultative Einrichtungen)
Karlsruhe School of Optics & Photonics (KSOP)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2018
Sprache Englisch
Identifikator ISSN: 2364-5504
KITopen-ID: 1000090646
Erschienen in Current directions in biomedical engineering
Verlag De Gruyter
Band 4
Heft 1
Seiten 385-388
Vorab online veröffentlicht am 22.09.2018
Schlagwörter Radiofrequency ablation, cardiac mapping, electrograms, signal processing.
Nachgewiesen in Dimensions
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