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Ruminal antimicrobial peptides as promising molecules to treat pathogenic bacteria, including resistant strains

Oyama, L. B.; Olleik, H.; Nery Teixeira, A. C.; Guidini, M. M.; Maresca, M.; Bazzolli, D.; Cookson, A. C.; Fuentes, N. F.; Vallin, H.; Pickup, J.; Mikut, R. ORCID iD icon; Hilpert, K.; Richards, J.; Wootton, M.; Edwards, J. E.; Perrier, J.; Hess, M.; Mantovani, H. C.; Creevey, C. J.; ... mehr

Abstract (englisch):

Antimicrobial peptides (AMPs) are promising drug candidates to treat multi-drug resistant bacteria. Commensal bacteria are considered to be part of the host and are known to produce various AMPs. The cow rumen presents an underexplored resource for the discovery of novel microbial enzymes and metabolites, including AMPs. Using functional screening and computational approaches, we identified novel AMPs from a rumen bacterial metagenome. Here, we show the results obtained with some of these AMPs tested against numerous bacterial pathogens, including resistant strains. Data shown that the ruminal AMPs: i) are active against bacterial pathogens, including resistant ones, ii) have low to no toxicity against human cells, iii) do not cause induction of resistance and iv) work in vivo. Our findings demonstrate that host derived AMPs obtained from the rumen microbiome may provide viable alternative antimicrobials for future therapeutic application.

Zugehörige Institution(en) am KIT Institut für Automation und angewandte Informatik (IAI)
Publikationstyp Poster
Publikationsjahr 2019
Sprache Englisch
Identifikator KITopen-ID: 1000093230
HGF-Programm 47.01.02 (POF III, LK 01) Biol.Netzwerke u.Synth.Regulat. IAI
Veranstaltung Gordon Research Conference - Antimicrobial Peptides: Mechanisms and Application: Realizing the Potential of Antimicrobial Host Defense Peptides for Human and Veterinary Medicine (GRC 2019), Lucca, Italien, 24.02.2019 – 01.03.2019
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