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Writing Behavior of Phospholipids in Polymer Pen Lithography (PPL) for Bioactive Micropatterns

Angelin, Alessandro 1; Bog, Uwe 2; Kumar, Ravi 2; Niemeyer, Christof M. ORCID iD icon 1; Hirtz, Michael ORCID iD icon 2
1 Institut für Biologische Grenzflächen (IBG), Karlsruher Institut für Technologie (KIT)
2 Karlsruhe Nano Micro Facility (KNMF), Karlsruher Institut für Technologie (KIT)


Lipid-based membranes play crucial roles in regulating the interface between cells and their external environment, the communication within cells, and cellular sensing. To study these important processes, various lipid-based artificial membrane models have been developed in recent years and, indeed, large-area arrays of supported lipid bilayers suit the needs of many of these studies remarkably well. Here, the direct-write scanning probe lithography technique called polymer pen lithography (PPL) was used as a tool for the creation of lipid micropatterns over large areas via polymer-stamp-mediated transfer of lipid-containing inks onto glass substrates. In order to better understand and control the lipid transfer in PPL, we conducted a systematic study of the influence of dwell time (i.e., duration of contact between tip and sample), humidity, and printing pressure on the outcome of PPL with phospholipids and discuss results in comparison to the more often studied dip-pen nanolithography with phospholipids. This is the first systematic study in phospholipid printing with PPL. Biocompatibility of the obtained substrates with up to two different ink compositions was demonstrated. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000095051
Veröffentlicht am 24.05.2019
DOI: 10.3390/polym11050891
Zitationen: 7
Web of Science
Zitationen: 5
Zitationen: 7
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische Grenzflächen (IBG)
Institut für Nanotechnologie (INT)
Karlsruhe Nano Micro Facility (KNMF)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2019
Sprache Englisch
Identifikator ISSN: 2073-4360
KITopen-ID: 1000095051
HGF-Programm 43.22.03 (POF III, LK 01) Printed Materials and Systems
Weitere HGF-Programme 47.02.01 (POF III, LK 01) Zellpopul.auf Biofunk.Oberflächen IBG-1
49.02.01 (POF III, LK 02) INT-KNMF Characterisation Lab
Erschienen in Polymers
Verlag MDPI
Band 11
Heft 5
Seiten Article: 891
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
Vorab online veröffentlicht am 15.05.2019
Schlagwörter polymer pen lithography; PPL; phospholipids; biomimetic membranes; supported lipid membranes; supported lipid bilayers; scanning probe lithography; DPN; In-house research
Nachgewiesen in Dimensions
Web of Science
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