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Molecular understanding of cytoneme-based Wnt trafficking

Mattes, Benjamin

Abstract (englisch):
Cell-to-cell communication by signaling proteins is essential to orchestrate development and tissue homeostasis in all multicellular organisms. The highly conserved family of Wnt proteins are important guiding cues to control these processes. Fundamental to this complex signaling network are relatively small and defined signaling centers in a given tissue that produce and distribute Wnt proteins. Adjacent, larger groups of cells respond to these spatial and temporal information in a concentration-dependent manner and adjust their transcriptional program. However, a regulated sequence of morphogen activity is required to generate a fine tuned communication network. Therefore, a controlled propagation machinery must ensure accurate signal distribution from the source to the surrounding tissue to initiate the correct developmental path.
In this thesis, I consolidated the knowledge of the molecular machinery controlling cytoneme formation in zebrafish development. I expanded this principle to other aspects of Wnt signaling such as cancer growth and tissue homeostasis. Via a screening approach, I identified the receptor tyrosine kinase Ror2 as a promoting factor for cellular protrusions in general and particularly for Wnt8a cytonemes in cultured cells and in vivo. ... mehr

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Volltext §
DOI: 10.5445/IR/1000096573
Veröffentlicht am 18.07.2019
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Toxikologie und Genetik (ITG)
Publikationstyp Hochschulschrift
Publikationsjahr 2019
Sprache Englisch
Identifikator KITopen-ID: 1000096573
Verlag Karlsruhe
Umfang XIX, 145 S.
Art der Arbeit Dissertation
Fakultät Fakultät für Chemie und Biowissenschaften (CHEM-BIO)
Institut Institut für Toxikologie und Genetik (ITG)
Prüfungsdatum 17.10.2018
Referent/Betreuer Assoc. Prof. S. Scholpp
Schlagwörter Wnt, Signalling, Zebrafish development, Cytoneme, Signalling filopodia, Ror2
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