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Evolution Shapes the Gene Expression Response to Oxidative Stress

Siauciunaite, Rima; Foulkes, Nicholas S.; Calabrò, Viola; Vallone, Daniela

Abstract:
Reactive oxygen species (ROS) play a key role in cell physiology and function. ROS represents a potential source of damage for many macromolecules including DNA. It is thought that daily changes in oxidative stress levels were an important early factor driving evolution of the circadian clock which enables organisms to predict changes in ROS levels before they actually occur and thereby optimally coordinate survival strategies. It is clear that ROS, at relatively low levels, can serve as an important signaling molecule and also serves as a key regulator of gene expression. Therefore, the mechanisms that have evolved to survive or harness these effects of ROS are ancient evolutionary adaptations that are tightly interconnected with most aspects of cellular physiology. Our understanding of these mechanisms has been mainly based on studies using a relatively small group of genetic models. However, we know comparatively little about how these mechanisms are conserved or have adapted during evolution under different environmental conditions. In this review, we describe recent work that has revealed significant species-specific differences in the gene expression response to ROS by exploring diverse organisms. ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/1000096583
Veröffentlicht am 02.08.2019
Originalveröffentlichung
DOI: 10.3390/ijms20123040
Scopus
Zitationen: 8
Web of Science
Zitationen: 8
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Prozessdatenverarbeitung und Elektronik (IPE)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2019
Sprache Englisch
Identifikator ISSN: 1422-0067
KITopen-ID: 1000096583
Erschienen in International journal of molecular sciences
Band 20
Heft 12
Seiten Art.Nr.: 3040
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
Vorab online veröffentlicht am 21.06.2019
Schlagwörter ROS; light; DNA damage; evolution; D-box; cavefish; Spalax
Nachgewiesen in Scopus
Web of Science
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