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Fine and ultrafine particles from indoor sources – Effects on healthy humans in a controlled exposure study and on lung epithelial cells in vitro

Schins, Roel P.F.; Hellack, Bryan; Soppa, Vanessa J.; Thongkam, Waluree; Albrecht, Catrin; Kaminski, Heinz; Kuhlbusch, Thomas A.J.; Hoffmann, Barbara

Abstract:
In recent years increasing concern has been expressed about the potential adverse health effects of particles from indoor sources. The aims of the EPIA project were: (1) to characterize potentially relevant indoor sources of (ultra)fine particles with respect to their emission levels and composition and (2) to investigate their adverse health effects. We investigated the effects of emissions from candle burning (CB), toasting of bread (TB) and sausage frying (FS) in a randomized, cross-over sham-controlled exposure study in healthy adults as well as in vitro in A549 human lung epithelial cells. Participants were exposed for 2 h to each of these sources at two different exposure levels, and examined before, during and after the exposures at defined time-intervals. We found transient associations between exposures and several respiratory and cardiovascular effects as well as inflammatory changes (e.g. lung function, blood pressure, arterial stiffness, interleukin-8 in nasal lavage/blood). Specific effects were found to depend strongly on the emission source and the selected exposure metric (e.g. size-specific particle mass concentration, size-specific particle number concentration, lung deposited surface area concentration). ... mehr

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Volltext §
DOI: 10.5445/IR/1000096837
Veröffentlicht am 25.07.2019
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Zugehörige Institution(en) am KIT Institut für Meteorologie und Klimaforschung - Atmosphärische Aerosolforschung (IMK-AAF)
Publikationstyp Vortrag
Jahr 2019
Sprache Englisch
Identifikator KITopen-ID: 1000096837
Veranstaltung 7th International Symposium on Ultrafine Particles, Air Quality and Climate (2019), Brüssel, Belgien, 15.05.2019 – 16.05.2019
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