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Quantity and quality of mental activities and the risk of incident mild cognitive impairment

Krell-Roesch, Janina 1; Syrjanen, Jeremy A.; Vassilaki, Maria; Machulda, Mary M.; Mielke, Michelle M.; Knopman, David S.; Kremers, Walter K.; Petersen, Ronald C.; Geda, Yonas E.
1 Institut für Sport und Sportwissenschaft (IfSS), Karlsruher Institut für Technologie (KIT)


To investigate whether timing, number, and frequency of mentally stimulating activities in midlife and late life are associated with the risk of incident mild cognitive impairment (MCI).
We conducted a prospective cohort study in the setting of the population-based Mayo Clinic Study of Aging in Olmsted County, Minnesota, including 2,000 individuals aged ≥70 years who were cognitively unimpaired at baseline and were followed for a median of 5.0 years. Participants completed a self-reported survey on timing, number, and frequency of engagement in 5 mentally stimulating activities (reading books, computer use, social activities, playing games, craft activities) at baseline.
The risk of incident MCI was significantly reduced for participants who engaged in social activities (hazard ratio [95% confidence interval] 0.80 [0.64–0.99]) and playing games (0.80 [0.66–0.98]) in both late life and midlife combined. Using a computer was associated with a decreased risk regardless of timing (not late life but midlife: 0.52 [0.31–0.88]; late life but not midlife: 0.70 [0.56–0.88]; late life and midlife: 0.63 [0.51–0.79]). ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000096840
Veröffentlicht am 29.07.2019
DOI: 10.1212/WNL.0000000000007897
Zitationen: 28
Web of Science
Zitationen: 20
Zitationen: 34
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2019
Sprache Englisch
Identifikator ISSN: 0028-3878, 1526-632X
KITopen-ID: 1000096840
Erschienen in Neurology
Verlag Lippincott, Williams & Wilkins (LWW)
Band 93
Heft 6
Seiten E548-E558
Vorab online veröffentlicht am 10.07.2019
Nachgewiesen in Dimensions
Web of Science
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