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Numerical simulation and in vitro examination of the flow behaviour within coronary stents

Melzer, Helena-Sophie; Ahrens, Ralf; Guber, Andreas E.; Dohse, Jakob

This paper discusses the influence of different design parameters of stents by mathematical flow simulations and flow measurements using micro-particle image velocimetry (micro-PIV). A stent strut may cause recirculation areas, which are considered to be the source of thrombosis and the process of in-stent restenosis. The simulations showed that a reduced strut height and a chamfering of the struts reduce these recirculation zones. The numerically determined results were compared with experimental investigations. For this purpose metallic stent structures were transferred into transparent channel systems made of PDMS. The experimental investigations confirm the results of numerical simulations.

Verlagsausgabe §
DOI: 10.5445/IR/1000098538
Veröffentlicht am 27.09.2019
DOI: 10.1515/cdbme-2019-0136
Zitationen: 2
Zitationen: 1
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Mikrostrukturtechnik (IMT)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 09.2019
Sprache Englisch
Identifikator ISSN: 2364-5504
KITopen-ID: 1000098538
HGF-Programm 47.02.07 (POF III, LK 01) Zellpopul.auf Biofunk.Oberflächen IMT
Erschienen in Current directions in biomedical engineering
Verlag De Gruyter
Band 5
Heft 1
Seiten 541–544
Vorab online veröffentlicht am 18.09.2019
Schlagwörter Stents; Thrombosis; In-Stent-Restenosis; mathematical flow simulations; micro-PIV; PDMS
Nachgewiesen in Scopus
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