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A marine plasmid hitchhiking vast phylogenetic and geographic distances

Petersen, Jörn; Vollmers, John; Ringel, Victoria; Brinkmann, Henner; Ellebrandt-Sperling, Claire; Spröer, Cathrin; Howat, Alexandra M.; Murrell, J. Colin; Kaster, Anne-Kristin

Abstract:
Horizontal gene transfer (HGT) plays an important role in bacterial evolution and serves as a driving force for bacterial diversity and versatility. HGT events often involve mobile genetic elements like plasmids, which can promote their own dissemination by associating with adaptive traits in the gene pool of the so-called mobilome. Novel traits that evolve through HGT can therefore lead to the exploitation of new ecological niches, prompting an adaptive radiation of bacterial species. In this study, we present phylogenetic, biogeographic, and functional analyses of a previously unrecognized RepL-type plasmid found in diversemembers of the marine Roseobacter group across the globe. Noteworthy, 100% identical plasmids were detected in phylogenetically and geographically distant bacteria, revealing a so-far overlooked, but environmentally highly relevant vector for HGT. The genomic and functional characterization of this plasmid showed a completely conserved backbone dedicated to replication, stability, and mobilization as well as an interchangeable gene cassette with highly diverse, but recurring motifs. The majority of the latter appear to be involved in mechanisms coping with toxins and/or pollutants in the marine environment. ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/1000098682
Veröffentlicht am 04.10.2019
Originalveröffentlichung
DOI: 10.1073/pnas.1905878116
Coverbild
Zugehörige Institution(en) am KIT Institut für Biologische Grenzflächen (IBG)
Publikationstyp Zeitschriftenaufsatz
Jahr 2019
Sprache Englisch
Identifikator ISSN: 0027-8424, 1091-6490
KITopen-ID: 1000098682
HGF-Programm 47.02.05 (POF III, LK 01)
Erschienen in Proceedings of the National Academy of Sciences of the United States of America
Band 116
Heft 41
Seiten 20568-20573
Vorab online veröffentlicht am 23.09.2019
Schlagworte horizontal gene transfer, Roseobacter group, RepL-type plasmid, chromate resistance
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