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Generation of a Simplified Brain Geometry for the Calculation of Local Cerebral Temperature using a 1D Hemodynamic Model

Daschner, Rosa 1; Krames, Lorena 1; Lutz, Yannick 1; Loewe, Axel ORCID iD icon 1; Dössel, Olaf 1; Cattaneo, Giorgio
1 Institut für Biomedizinische Technik (IBT), Karlsruher Institut für Technologie (KIT)


In Western countries, stroke is the third-most cause of death; 35– 55% of the survivors experience permanent disability. Mild therapeutic hypothermia (TH) showed neuroprotective effect in patients returning from cardiac arrest and is therefore assumed to decrease stroke induced cerebral damage. Recently, an intracarotid cooling sheath was developed to induce local TH in the penumbra using the cooling effect of cerebral blood flow via collaterals. Computational modeling provides unique opportunities to predict the resulting cerebral temperature without invasive procedures. In this work, we generated a simplified brain model to establish a cerebral temperature calculation using Pennes’ bio-heat equation and a 1D hemodynamics model of the cranial artery tree. In this context, we performed an extensive literature research to assign the terminal segments of the latter to the corresponding perfused tissue. Using the intracarotid cooling method, we simulated the treatment with TH for different degrees of stenosis in the middle cerebral artery (MCA) and analyzed the resulting temperature spatialtemporal distributions of the brain and the systemic body considering the influence of the collaterals on the effect of cooling.

Verlagsausgabe §
DOI: 10.5445/IR/1000098828
Veröffentlicht am 09.10.2019
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biomedizinische Technik (IBT)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 09.2019
Sprache Englisch
Identifikator ISSN: 2364-5504
KITopen-ID: 1000098828
Erschienen in Current directions in biomedical engineering
Verlag De Gruyter
Band 5
Heft 1
Seiten 529–532
Vorab online veröffentlicht am 18.09.2019
Schlagwörter local therapeutic hypothermia, collaterals, intracarotid cooling, targeted temperature management, computational temperature modeling, ischemic stroke
Nachgewiesen in Dimensions
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