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Modeling of the Human Cerebral Collateral Circulation: Evaluation of the Impact on the Cerebral Perfusion in Case of Ischemic Stroke

Krames, Lorena 1; Daschner, Rosa 1; Lutz, Yannick 1; Loewe, Axel ORCID iD icon 1; Dössel, Olaf 1; Cattaneo, Giorgio
1 Institut für Biomedizinische Technik (IBT), Karlsruher Institut für Technologie (KIT)


Stroke is the third-most cause of death in developed countries. A new promising treatment method in case of an ischemic stroke is selective intracarotid blood cooling combined with mechanical artery recanalization. However, the control of the treatment requires invasive or MRI-assisted measurement of cerebral temperature. An auspicious alternative is the use of computational modeling. In this work, we extended an existing 1D hemodynamics model including the characteristics of the anterior, middle and posterior cerebral artery. Furthermore, seven ipsilateral anastomoses were additionally integrated for each hemisphere. A potential stenosis was placed into the M1 segment of the middle cerebral artery, due to the highest risk of occlusion there. The extended model was evaluated for various degrees of collateralization (“poor”, “partial” and “good”) and degrees of stenosis (0%, 50%, 75% and 99.9%). Moreover, cerebral autoregulation was considered in the model. The higher the degree of collateralization and the degree of stenosis, the higher was the blood flow through the collaterals. Hence, a patient with a good collateralization could compensate a higher degree of occlusion and potentially has a better outcome after an ischemic stroke. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000098829
Veröffentlicht am 16.10.2019
DOI: 10.1515/cdbme-2019-0134
Zitationen: 1
Zitationen: 2
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biomedizinische Technik (IBT)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 09.2019
Sprache Englisch
Identifikator ISSN: 2364-5504
KITopen-ID: 1000098829
Erschienen in Current directions in biomedical engineering
Verlag De Gruyter
Band 5
Heft 1
Seiten 533–536
Vorab online veröffentlicht am 18.09.2019
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