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Discovery and Validation of Banana Intake Biomarkers Using Untargeted Metabolomics in Human Intervention and Cross-sectional Studies

Vázquez-Manjarrez, Natalia; Weinert, Christoph H; Ulaszewska, Maria M; Mack, Carina I; Micheau, Pierre; Pétéra, Mélanie; Durand, Stephanie; Pujos-Guillot, Estelle; Egert, Björn; Mattivi, Fulvio; Bub, Achim; Dragsted, Lars Ove; Kulling, Sabine E; Manach, Claudine

Abstract (englisch):
Background:Banana is one of the most widely consumed fruits in the world. However, information regarding its healtheffects is scarce. Biomarkers of banana intake would allow a more accurate assessment of its consumption in nutritionstudies.Objectives:Using an untargeted metabolomics approach, we aimed to identify the banana-derived metabolites presentin urine after consumption, including new candidate biomarkers of banana intake.Methods:A randomized controlled study with a crossover design was performed on 12 healthy subjects (6 men, 6women, mean±SD age: 30.0±4.9 y; mean±SD BMI: 22.5±2.3 kg/m2). Subjects underwent 2 dietary interventions:1) 250 mL control drink (Fresubin 2 kcal fiber, neutral flavor; Fresenius Kabi), and2) 240 g banana+150 mL control drink.Twenty-four-hour urine samples were collected and analyzed with ultra-performance liquid chromatography coupled to aquadrupole time-of-flight MS and 2-dimensional GC-MS. The discovered biomarkers were confirmed in a cross-sectionalstudy [KarMeN (Karlsruhe Metabolomics and Nutrition study)] in which 78 subjects (mean BMI: 22.8; mean age: 47y) were selected reflecting high intake (126–378 g/d), low intake (47.3–94.5 g/d), and nonconsumption of banana. ... mehr

DOI: 10.1093/jn/nxz125
Zitationen: 11
Zitationen: 14
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 10.2019
Sprache Englisch
Identifikator ISSN: 0022-3166, 1541-6100
KITopen-ID: 1000099054
Erschienen in The journal of nutrition
Verlag Oxford University Press (OUP)
Band 149
Heft 10
Seiten 1701–1713
Vorab online veröffentlicht am 26.06.2019
Schlagwörter banana; biomarkers of intake; dietary assessment; dopamine; methoxyeugenol; nutrimetabolomics; salsolinol; tetrahydro-β-carbolines; untargeted
Nachgewiesen in Dimensions
Web of Science
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