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A Dietary Intervention of Bioactive Enriched Foods Aimed at Adults at Risk of Metabolic Syndrome: Protocol and Results from PATHWAY-27 Pilot Study

Bub, Achim; Malpuech-Brugère, Corinne; Orfila, Caroline; Amat, Julien; Arianna, Alice; Blot, Adeline; Di Nunzio, Mattia; Holmes, Melvin; Kertész, Zsófia; Marshall, Lisa; Nemeth, Imola; Ricciardiello, Luigi; Seifert, Stephanie; Sutulic, Samantha; Ulaszewska, Marynka; Bordoni, Alessandra

Abstract (englisch):
Around a quarter of the global adult population have metabolic syndrome (MetS) and therefore increased risk of cardiovascular mortality and diabetes. Docosahexaenoic acid, oat beta-glucan and grape anthocyanins have been shown to be effective in reducing MetS risk factors when administered as isolated compounds, but their effect when administered as bioactive-enriched foods has not been evaluated. Objective: The overall aim of the PATHWAY-27 project was to evaluate the effectiveness of bioactive-enriched food consumption on improving risk factors of MetS. A pilot study was conducted to assess which of five bioactive combinations provided within three different food matrices (bakery, dairy or egg) were the most effective in adult volunteers. The trial also evaluated the feasibility of production, consumer acceptability and gastrointestinal tolerance of the bioactive-enriched food. Method: The study included three monocentric, parallel-arm, double-blind, randomised, dietary intervention trials without a placebo. Each recruiting centre tested the five bioactive combinations within a single food matrix. Results: The study was completed by 167 participants (74 male, 93 female). ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/1000099057
Veröffentlicht am 17.10.2019
Coverbild
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Jahr 2019
Sprache Englisch
Identifikator ISSN: 2072-6643
KITopen-ID: 1000099057
Erschienen in Nutrients
Band 11
Heft 8
Seiten 1814
Bemerkung zur Veröffentlichung This article belongs to the Special Issue Dietary Bioactives and Human Health
Vorab online veröffentlicht am 06.08.2019
Schlagworte nutritional intervention trials; functional food; metabolic syndrome; docosahexaenoic acid; oat beta-glucan; anthocyanins; bioactive; short chain fatty acid; egg; bakery; dairy
Nachgewiesen in Web of Science
Scopus
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