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Bottom-Up Assembly of DNA–Silica Nanocomposites into Micrometer-Sized Hollow Spheres

Hu, Y.; Grösche, M.; Sheshachala, S.; Oelschlaeger, C.; Willenbacher, N.; Rabe, K. S.; Niemeyer, C. M.

Abstract (englisch):
Although DNA nanotechnology has developed into a highly innovative and lively field of research at the interface between chemistry, materials science, and biotechnology, there is still a great need for methodological approaches for bridging the size regime of DNA nanostructures with that of micrometer‐ and millimeter‐sized units for practical applications. We report on novel hierarchically structured composite materials from silica nanoparticles and DNA polymers that can be obtained by self‐assembly through the clamped hybridization chain reaction. The nanocomposite materials can be assembled into thin layers within microfluidically generated water‐in‐oil droplets to produce mechanically stabilized hollow spheres with uniform size distributions at high throughput rates. The fact that cells can be encapsulated in these microcontainers suggests that our concept not only contributes to the further development of supramolecular bottom‐up manufacturing, but can also be exploited for applications in the life sciences.

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Verlagsausgabe §
DOI: 10.5445/IR/1000099778/pub
Veröffentlicht am 15.01.2020
DOI: 10.1002/anie.201910606
Zitationen: 7
Web of Science
Zitationen: 6
Zitationen: 6
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische Grenzflächen (IBG)
Institut für Mechanische Verfahrenstechnik und Mechanik (MVM)
Publikationstyp Zeitschriftenaufsatz
Publikationsdatum 25.11.2019
Sprache Englisch
Identifikator ISSN: 0044-8249, 0570-0833, 1433-7851, 1521-3757, 1521-3773
KITopen-ID: 1000099778
HGF-Programm 47.02.01 (POF III, LK 01) Zellpopul.auf Biofunk.Oberflächen IBG-1
Erschienen in Angewandte Chemie / International edition
Verlag John Wiley and Sons
Band 58
Heft 48
Seiten 17269-17272
Vorab online veröffentlicht am 18.10.2019
Nachgewiesen in Web of Science
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