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Ultrashort Pulsed Laser Surface Patterning of Titanium to Improve Osseointegration of Dental Implants

Zwahr, Christoph; Welle, Alexander ORCID iD icon 1; Weingärtner, Tobias 1; Heinemann, Christiane; Kruppke, Benjamin; Gulow, Nikolai; Holthaus, Marzellus große; Fabián Lasagni, Andrés
1 Karlsruhe Nano Micro Facility (KNMF), Karlsruher Institut für Technologie (KIT)

Abstract:

Ultrashort pulsed direct laser interference patterning (DLIP) is used to generate hierarchical line-like patterns on titanium surfaces to control cell adhesion and spreading on dental implants, thereby improving osseointegration. The DLIP structures have spatial periods of 3, 5, 10, and 17 μm. They are produced using a laser source with a pulse duration of 10 ps and cumulated energy densities between 0.1 and 78.9 J cm−2. Laser-induced periodic surface structures (LIPSS) and submicron features are obtained on the treated samples. The DLIP treatment leads to the development of a thick titanium oxide layer, which is imaged and quantified using time-of-flight secondary ion mass spectrometry (ToF-SIMS). Several days (30–56) after the laser treatment, specimens with larger spatial periods are hydrophilic, whereas samples with spatial periods of 3 μm are hydrophobic. Seeded human osteoblasts on the laser-structured samples show 2.5 times higher cell numbers after 7 days in vitro culture compared with osteoblasts on a grit-blasted and etched reference sample. Finally, cell adhesion to a structured 3D dental implant is demonstrated.


Verlagsausgabe §
DOI: 10.5445/IR/1000099892
Veröffentlicht am 18.11.2019
Originalveröffentlichung
DOI: 10.1002/adem.201900639
Scopus
Zitationen: 22
Web of Science
Zitationen: 21
Dimensions
Zitationen: 23
Cover der Publikation
Zugehörige Institution(en) am KIT Karlsruhe Nano Micro Facility (KNMF)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 12.2019
Sprache Englisch
Identifikator ISSN: 1438-1656, 1527-2648
KITopen-ID: 1000099892
HGF-Programm 43.22.01 (POF III, LK 01) Functionality by Design
Weitere HGF-Programme 49.02.06 (POF III, LK 02) ToF-SIMS
Erschienen in Advanced engineering materials
Verlag Deutsche Gesellschaft für Materialkunde e.V. (DGM)
Band 21
Heft 12
Seiten Art.Nr. 1900639
Vorab online veröffentlicht am 25.10.2019
Schlagwörter 2016-017-015889 ToF-SIMS AES
Nachgewiesen in Dimensions
Scopus
Web of Science
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