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Preperative protein precipitation - Strategies for process development, integration, and monitoring

Großhans, Steffen

Abstract (englisch):

This PhD thesis contributes to the field of biopharmaceutical process development and production. In the pharmaceutical industry biopharmaceuticals, mostly protein-based drugs, are gaining more and more importance compared to classical, small molecule drugs. They often bind more specifically to the target or receptor. At the same time they trigger a complex mode of action. This often leads to higher efficacy, while at the same time side effects are reduced. The complex mode of action also opens up the possibility of treating new diseases or those for which there is currently no therapy available. In the past, the biggest growth in the biopharmaceutical market has taken place in the field of cancer immunotherapy. Against the background of an aging society, the challenge of fighting cancer will continue to grow. In addition, the demand for therapies for the treatment of autoimmune diseases, diabetes, and Alzheimer's disease will continue to rise as well. All biopharmaceutical products have high development and production costs in common. The increasing demand for new products and higher production capacities stands in contrast to the ever scarcer healthcare budgets. ... mehr

Volltext §
DOI: 10.5445/IR/1000100043
Veröffentlicht am 20.11.2019
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Hochschulschrift
Publikationsjahr 2019
Sprache Englisch
Identifikator KITopen-ID: 1000100043
Verlag Karlsruher Institut für Technologie (KIT)
Umfang XX, 183 S.
Art der Arbeit Dissertation
Fakultät Fakultät für Chemieingenieurwesen und Verfahrenstechnik (CIW)
Institut Institut für Bio- und Lebensmitteltechnik (BLT)
Prüfungsdatum 07.10.2019
Projektinformation nextBioPharmDSP (EU, H2020, 635557)
Referent/Betreuer Hubbuch, J.
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