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A one-step biofunctionalization strategy of electrospun scaffolds enables spatially selective presentation of biological cues

Wieringa, Paul; Girao, Andre; Truckenmuller, Roman; Welle, Alexander; Micera, Silvestro; van Wezel, Richard; Moroni, Lorenzo

Abstract:
To recapitulate the heterogeneous complexity of tissues in our body with synthetic mimics of the extracellular matrix (ECM), it is important to develop methods that can easily allow the selective functionalization of defined spatial domains. Here, we introduce a facile method to functionalize microfibrillar meshes with different reactive groups able to bind biological moieties in a one-step reaction. The resulting scaffolds proved to selectively support a differential neurite growth after being seeded with dorsal root ganglia. Considering the general principles behind the method developed, this is a promising strategy to realize enhanced biomimicry of native ECM for different regenerative medicine applications.

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Volltext §
DOI: 10.5445/IR/1000100309
Veröffentlicht am 27.11.2019
Originalveröffentlichung
DOI: 10.1101/850875
Dimensions
Zitationen: 2
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Funktionelle Grenzflächen (IFG)
Karlsruhe Nano Micro Facility (KNMF)
Publikationstyp Forschungsbericht/Preprint
Publikationsjahr 2019
Sprache Englisch
Identifikator KITopen-ID: 1000100309
HGF-Programm 43.22.01 (POF III, LK 01) Functionality by Design
Weitere HGF-Programme 49.02.06 (POF III, LK 02) ToF-SIMS
Schlagwörter 2014-011-003105 ToF-SIMS
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