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Carbon-nanotube reinforcement of DNA-silica nanocomposites yields programmable and cell-instructive biocoatings

Hu, Yong; Domínguez, Carmen M.; Bauer, Jens; Weigel, Simone; Schipperges, Alessa; Oelschlaeger, Claude; Willenbacher, Norbert; Keppler, Stephan; Bastmeyer, Martin; Heißler, Stefan; Wöll, Christof; Scharnweber, Tim; Rabe, Kersten S.; Niemeyer, Christof M.

Abstract (englisch):
Biomedical applications require substrata that allow for the grafting, colonization and control of eukaryotic cells. Currently available materials are often limited by insufficient possibilities for the integration of biological functions and means for tuning the mechanical properties. We report on tailorable nanocomposite materials in which silica nanoparticles are interwoven with carbon nanotubes by DNA polymerization. The modular, well controllable and scalable synthesis yields materials whose composition can be gradually adjusted to produce synergistic, non-linear mechanical stiffness and viscosity properties. The materials were exploited as substrata that outperform conventional culture surfaces in the ability to control cellular adhesion, proliferation and transmigration through the hydrogel matrix. The composite materials also enable the construction of layered cell architectures, the expansion of embryonic stem cells by simplified cultivation methods and the on-demand release of uniformly sized stem cell spheroids.

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Verlagsausgabe §
DOI: 10.5445/IR/1000100651
Veröffentlicht am 09.12.2019
DOI: 10.1038/s41467-019-13381-1
Zitationen: 9
Web of Science
Zitationen: 11
Zitationen: 10
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische Grenzflächen (IBG)
Institut für Funktionelle Grenzflächen (IFG)
Institut für Mechanische Verfahrenstechnik und Mechanik (MVM)
Zoologisches Institut (ZOO)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 12.2019
Sprache Englisch
Identifikator ISSN: 2041-1723
KITopen-ID: 1000100651
HGF-Programm 47.02.01 (POF III, LK 01) Zellpopul.auf Biofunk.Oberflächen IBG-1
Erschienen in Nature Communications
Verlag Nature Research
Band 10
Heft 1
Seiten Article No.5522
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
Vorab online veröffentlicht am 04.12.2019
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