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Biosynthesized Silver Nanoparticle (AgNP) From Pandanus odorifer Leaf Extract Exhibits Anti-metastasis and Anti-biofilm Potentials

Hussain, Afzal; Alajmi, Mohamed F.; Khan, Meraj A.; Pervez, Syed A. 1; Ahmed, Faheem; Amir, Samira; Husain, Fohad M.; Khan, Mohd S.; Shaik, Gouse M.; Hassan, Iftekhar; Khan, Rais A.; Rehman, Md. Tabish
1 Center for Electrochemical Energy Storage Ulm & Karlsruhe (CELEST), Karlsruher Institut für Technologie (KIT)


Cancer and the associated secondary bacterial infections are leading cause of mortality, due to the paucity of effective drugs. Here, we have synthesized silver nanoparticles (AgNPs) from organic resource and confirmed their anti-cancer and anti-microbial potentials. Microwave irradiation method was employed to synthesize AgNPs using Pandanus odorifer leaf extract. Anti-cancer potential of AgNPs was evaluated by scratch assay on the monolayer of rat basophilic leukemia (RBL) cells, indicating that the synthesized AgNPs inhibit the migration of RBL cells. The synthesized AgNPs showed MIC value of 4–16 µg/mL against both Gram +ve and Gram -ve bacterial strains, exhibiting the anti-microbial potential. Biofilm inhibition was recorded at sub- MIC values against Gram +ve and Gram -ve bacterial strains. Violacein and alginate productions were reduced by 89.6 and 75.6%, respectively at 4 and 8 µg/mL of AgNPs, suggesting anti-quorum sensing activity. Exopolysaccharide production was decreased by 61–79 and 84% for Gram +ve and Gram -ve pathogens respectively. Flagellar driven swarming mobility was also reduced significantly. Furthermore, In vivo study confirmed their tolerability in mice, indicating their clinical perspective. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000100766
Veröffentlicht am 11.12.2019
DOI: 10.3389/fmicb.2019.00008
Zitationen: 67
Web of Science
Zitationen: 59
Zitationen: 72
Cover der Publikation
Zugehörige Institution(en) am KIT Helmholtz-Institut Ulm (HIU)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2019
Sprache Englisch
Identifikator ISSN: 1664-302X
KITopen-ID: 1000100766
HGF-Programm 37.01.01 (POF III, LK 01) Fundamentals and Materials
Erschienen in Frontiers in microbiology
Verlag Frontiers Media SA
Band 10
Seiten Art. Nr.: 8
Vorab online veröffentlicht am 12.02.2019
Schlagwörter silver nanoparticles (AgNPs), anti-metastasis, anti-biofilm, quorum sensing, molecular docking
Nachgewiesen in Web of Science
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