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Improved emotion regulation after neurofeedback: A single-arm trial in patients with borderline personality disorder

Zaehringer, J.; Ende, G.; Santangelo, Philip 1; Kleindienst, N.; Ruf, M.; Bertsch, K.; Bohus, M.; Schmahl, C.; Paret, C.
1 Institut für Sport und Sportwissenschaft (IfSS), Karlsruher Institut für Technologie (KIT)


Real-time functional magnetic resonance imaging (fMRI) neurofeedback training of amygdala hemodynamic activity directly targets a neurobiological mechanism, which contributes to emotion regulation problems in borderline personality disorder (BPD). However, it remains unknown which outcome measures can assess changes in emotion regulation and affective instability, associated with amygdala downregulation in a clinical trial. The current study directly addresses this question. Twenty-four female patients with a DSM-IV BPD diagnosis underwent four runs of amygdala neurofeedback. Before and after the training, as well as at a six-weeks follow-up assessment, participants completed measures of emotion dysregulation and affective instability at diverse levels of analysis (verbal report, clinical interview, ecological momentary assessment, emotion-modulated startle, heart rate variability, and fMRI). Participants were able to downregulate their amygdala blood oxygen-dependent (BOLD) response with neurofeedback. There was a decrease of BPD symptoms as assessed with the Zanarini rating scale for BPD (ZAN-BPD) and a decrease in emotion-modulated startle to negative pictures after training. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000104258
Veröffentlicht am 16.12.2019
DOI: 10.1016/j.nicl.2019.102032
Zitationen: 32
Web of Science
Zitationen: 27
Zitationen: 44
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2019
Sprache Englisch
Identifikator ISSN: 2213-1582
KITopen-ID: 1000104258
Erschienen in NeuroImage: Clinical
Verlag Elsevier
Band 24
Seiten Art.-Nr.: 102032
Schlagwörter Borderline personality disorder; Amygdala; Real-time fMRI; Neurofeedback; Emotion regulation
Nachgewiesen in Dimensions
Web of Science
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