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Anti-Tumor Activity of Doxorubicin-loaded Boehmite Nanocontainers

Seidl, Carmen; Simonato, Sara; Zittel, Eva; Schepers, Ute; Feldmann, Claus

Doxorubicin-filled boehmite nanocontainers, DOX@γ-AlO(OH), with a mean diameter of 40 nm and a wall thickness of 10 nm are prepared via a microemulsion strategy and studied as drug carriers for cancer treatment. Nanocontainer structure and drug load are examined in detail based on different analytical tools. The DOX load is optimized on highest load at lowest side effects according to blood counts. Cell uptake, DOX-based fluorescence detection and systemic toxicity are evaluated based on in vitro and in vivo models. Toxicity and activity of the DOX@AlO(OH) nanocontainers are compared with non-filled AlO(OH) hollow spheres and free DOX as references and show promising results. An orthotopic breast cancer BALB/c mouse model validates the activity of DOX@AlO(OH) in vivo at lower side effects than for free DOX.

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Verlagsausgabe §
DOI: 10.5445/IR/1000104933
Veröffentlicht am 14.01.2020
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Anorganische Chemie (AOC)
Institut für Toxikologie und Genetik (ITG)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 12.2019
Sprache Englisch
Identifikator ISSN: 0044-2313
KITopen-ID: 1000104933
HGF-Programm 47.01.01 (POF III, LK 01) Biol.Netzwerke u.Synth.Regulat. ITG+ITC
Erschienen in Zeitschrift für anorganische und allgemeine Chemie
Verlag John Wiley and Sons
Band 645
Heft 24
Seiten 1372–1378
Vorab online veröffentlicht am 12.12.2019
Schlagwörter Nanocontainer, Doxorubicin, Tumor, Metastastasis, Side effects
Nachgewiesen in Web of Science
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