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Quantification of Urinary Phenyl-γ-Valerolactones and Related Valeric Acids in Human Urine on Consumption of Apples

Anesi, Andrea; Mena, Pedro; Bub, Achim; Ulaszewska, Marynka; Del Rio, Daniele; Kulling, Sabine E.; Mattivi, Fulvio

Abstract (englisch):
Flavan-3-ols are dietary bioactive molecules that have beneficial effects on human health and reduce the risk of various diseases. Monomeric flavan-3-ols are rapidly absorbed in the small intestine and released in the blood stream as phase II conjugates. Polymeric flavan-3-ols are extensively metabolized by colonic gut microbiota into phenyl-γ-valerolactones and their related phenylvaleric acids. These molecules are the main circulating metabolites in humans after the ingestion of flavan-3-ol rich-products; nevertheless, they have received less attention and their role is not understood yet. Here, we describe the quantification of 8 phenyl-γ-valerolactones and 3 phenylvaleric acids in the urine of 11 subjects on consumption of apples by using UHPLC-ESI-Triple Quad-MS with pure reference compounds. Phenyl-γ-valerolactones, mainly as sulfate and glucuronic acid conjugates, reached maximum excretion between 6 and 12 after apple consumption, with a decline thereafter. Significant differences were detected in the cumulative excretion rates within subjects and in the ratio of dihydroxyphenyl-γ-valerolactone sulfate to glucuronide conjugates. ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/1000105196
Veröffentlicht am 23.01.2020
DOI: 10.3390/metabo9110254
Zitationen: 6
Web of Science
Zitationen: 6
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2019
Sprache Englisch
Identifikator ISSN: 2218-1989
KITopen-ID: 1000105196
Erschienen in Metabolites
Verlag MDPI
Band 9
Heft 11
Seiten 254
Vorab online veröffentlicht am 29.10.2019
Schlagwörter LC-MS; LC-MS/MS; apples; flavan-3ols; metabolic phenotype; phenyl-γ-valerolactone; phenylvaleric acid; proanthocyanidins; urine
Nachgewiesen in Scopus
Web of Science
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