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Hydrogels with Preprogrammable Lifetime via UV-Induced Polymerization and Degradation

Scheiger, J. M.; Levkin, P. A.

Abstract:
Hydrogels are 3D networks infused with water. When formed via radical polymerization, inherently stable hydrogels are created due to stable covalent carbon–carbon bonds. As such, they remain static soft scaffolds, unlike the dynamic tissue they are often compared to. Herein, a hydrogel capable of autonomously converting from a liquid hydrogel precursor solution into a solid hydrogel for a defined period of time, followed by a further transformation back into a liquid polymer solution, is designed. These antagonistic processes are initiated by the same UV light, which is used as stimulus for both a photopolymerization and a photodegradation simultaneously. It is demonstrated how the lifetime of the hydrogel state can be controlled and visualized on the minute scale. Both the photopolymerization and the photodegradation reactions are studied with various methods such as NMR, IR, and confocal microscopy. The different stages of the transformation, e.g., the hydrogel precursor (liquid), hydrogel (solid), and degraded hydrogel (liquid) are investigated with rheometry, viscosimetry, dynamic light scattering, and gel permeation chromatography. ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/1000105360
Veröffentlicht am 16.07.2020
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Organische Chemie (IOC)
Institut für Biologische und Chemische Systeme (IBCS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2020
Sprache Englisch
Identifikator ISSN: 1057-9257, 1099-0712, 1616-301X, 1616-3028
KITopen-ID: 1000105360
HGF-Programm 47.01.01 (POF III, LK 01)
Biol.Netzwerke u.Synth.Regulat. ITG+ITC
Erschienen in Advanced functional materials
Band 30
Heft 26
Seiten 1909800
Vorab online veröffentlicht am 09.01.2020
Nachgewiesen in Scopus
Web of Science
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