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Out of balance – postural control in cancer patients before and after neurotoxic chemotherapy

Müller, Jana; Ringhof, Steffen; Vollmer, Maxmilian; Jäger, Laura Bettina; Stein, Thorsten; Weiler, Markus; Wiskemann, Joachim

Abstract (englisch):
Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect deriving from neurotoxic chemotherapeutic agents. The underlying nerve injury can affect proprioception causing impaired postural control, gait difficulties and a higher risk of falling. Overall, the symptoms and functional limitations negatively affect patients’ independence and quality of life.
Research question
Our objective was to analyze postural control in cancer patients before and after neurotoxic chemotherapy and to compare these data to healthy controls.
Participants were 35 cancer patients (PAT) and 35 healthy, one-to-one gender, age, height, and weight matched controls (HMC). Postural control of HMC was tested once, whereas PAT were tested prior to (PATpre) and three weeks after completion of neurotoxic chemotherapy (PATpost). Temporal, spatial and frequency domain measures of the center of pressure (COP) were calculated using a force plate. The following balance conditions were analyzed: bipedal stance with open (BPEO) and closed eyes (BPEC), semi-tandem (STEO, STEC) and monopedal stance (MPEO). CIPN was assessed clinically (Total Neuropathy Score) and via questionnaire. ... mehr

DOI: 10.1016/j.gaitpost.2020.01.012
Zitationen: 3
Web of Science
Zitationen: 2
Zitationen: 4
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 03.2020
Sprache Englisch
Identifikator ISSN: 0966-6362
KITopen-ID: 1000105519
Erschienen in Gait & posture
Verlag Elsevier
Band 77
Seiten 156-163
Schlagwörter Balance, Cancer, Chemotherapy, Peripheral neuropathy, Postural stability, Proprioception
Nachgewiesen in Scopus
Web of Science
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