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Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation

Begg, Gordon A.; Swoboda, Peter P.; Karim, Rashed; Oesterlein, Tobias; Rhode, Kawal; Holden, Arun V.; Greenwood, John P.; Shantsila, Eduard; Lip, Gregory Y. H.; Plein, Sven; Tayebjee, Muzahir H.

Abstract:
Background: Using cardiovascular magnetic resonance imaging (CMR), it is possible to detect diffuse fibrosis of the left ventricle (LV) in patients with atrial fibrillation (AF), which may be independently associated with recurrence of AF after ablation. By conducting CMR, clinical, electrophysiology and biomarker assessment we planned to investigate LV myocardial fibrosis in patients undergoing AF ablation.
Methods: LV fibrosis was assessed by T1 mapping in 31 patients undergoing percutaneous ablation for AF. Galectin-3, coronary sinus type I collagen C terminal telopeptide (ICTP), and type III procollagen N terminal peptide were measured with ELISA. Comparison was made between groups above and below the median for LV extracellular volume fraction (ECV), followed by regression analysis.
Results: On linear regression analysis LV ECV had significant associations with invasive left atrial pressure (Beta 0.49, P = 0.008) and coronary sinus ICTP (Beta 0.75, P < 0.001), which remained significant on multivariable regression.
Conclusion: LV fibrosis in patients with AF is associated with left atrial pressure and invasively measured levels of ICTP turnover biomarker.

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Verlagsausgabe §
DOI: 10.5445/IR/1000117567
Veröffentlicht am 06.03.2020
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biomedizinische Technik (IBT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2020
Sprache Englisch
Identifikator ISSN: 1097-6647, 1532-429X
KITopen-ID: 1000117567
Erschienen in Journal of cardiovascular magnetic resonance
Band 22
Heft 1
Seiten Art. Nr.: 13
Vorab online veröffentlicht am 10.02.2020
Schlagwörter Atrial fibrillation, Cardiovascular magnetic resonance imaging, Fibrosis, Biomarkers, Voltage mapping
Nachgewiesen in Web of Science
Scopus
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