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Lanthanide conjugates as versatile instruments for therapy and diagnostics

Herlan, Claudine; Bräse, Stefan

Abstract:
Lanthanides have demonstrated outstanding properties in many fields of research including biology and medicinal chemistry. Their unique luminescence and magnetic properties make them the metals of choice for next generation theranostics that efficiently combine the two central pillars of medicine – diagnostics and therapy. Attached to targeting units, lanthanide complexes pave the way for real-time imaging of drug uptake and distribution as well as specific regulation of subcellular processes with few side effects. This enables individualized treatment options for severe diseases characterized by altered cell expression. The highly diverse results achieved as well as insights into the challenges that research in this area has to face in the upcoming years will be summarized in the present review.

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Verlagsausgabe §
DOI: 10.5445/IR/1000117604
Veröffentlicht am 09.03.2020
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Organische Chemie (IOC)
Institut für Biologische und Chemische Systeme (IBCS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2020
Sprache Englisch
Identifikator ISSN: 1477-9226, 1477-9234
KITopen-ID: 1000117604
HGF-Programm 47.01.01 (POF III, LK 01)
Biol.Netzwerke u.Synth.Regulat. ITG+ITC
Erschienen in Dalton transactions
Band 49
Heft 8
Seiten 2397–2402
Vorab online veröffentlicht am 14.01.2020
Nachgewiesen in Web of Science
Scopus
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