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Urinary NMR Profiling in Pediatric Acute Kidney Injury—A Pilot Study

Muhle-Goll, Claudia ORCID iD icon 1,2; Eisenmann, Philipp 2; Luy, Burkhard ORCID iD icon 1,2; Kölker, Stefan; Tönshoff, Burkhard; Fichtner, Alexander; Westhoff, Jens H.
1 Institut für Biologische Grenzflächen (IBG), Karlsruher Institut für Technologie (KIT)
2 Institut für Organische Chemie (IOC), Karlsruher Institut für Technologie (KIT)


Acute kidney injury (AKI) in critically ill children and adults is associated with significant short- and long-term morbidity and mortality. As serum creatinine- and urine output-based definitions of AKI have relevant limitations, there is a persistent need for better diagnostics of AKI. Nuclear magnetic resonance (NMR) spectroscopy allows for analysis of metabolic profiles without extensive sample manipulations. In the study reported here, we examined the diagnostic accuracy of NMR urine metabolite patterns for the diagnosis of neonatal and pediatric AKI according to the Kidney Disease: Improving Global Outcomes (KDIGO) definition. A cohort of 65 neonatal and pediatric patients (0–18 years) with established AKI of heterogeneous etiology was compared to both a group of apparently healthy children (n = 53) and a group of critically ill children without AKI (n = 31). Multivariate analysis identified a panel of four metabolites that allowed diagnosis of AKI with an area under the receiver operating characteristics curve (AUC-ROC) of 0.95 (95% confidence interval 0.86–1.00). Especially urinary citrate levels were significantly reduced whereas leucine and valine levels were elevated. ... mehr

Verlagsausgabe §
DOI: 10.5445/IR/1000117920
Veröffentlicht am 17.04.2020
DOI: 10.3390/ijms21041187
Zitationen: 10
Web of Science
Zitationen: 9
Zitationen: 9
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische Grenzflächen (IBG)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2020
Sprache Englisch
Identifikator ISSN: 1422-0067
KITopen-ID: 1000117920
HGF-Programm 47.02.04 (POF III, LK 01) Zellpopul.auf Biofunk.Oberflächen IBG-4
Erschienen in International journal of molecular sciences
Verlag MDPI
Band 21
Heft 4
Seiten Article No.1187
Vorab online veröffentlicht am 11.02.2020
Schlagwörter acute kidney injury; metabolomics; urine; NMR spectroscopy; multivariate analysis
Nachgewiesen in Web of Science
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