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A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing

Rolinger, L. 1; Rüdt, M. 1; Hubbuch, J. 1
1 Institut für Bio- und Lebensmitteltechnik (BLT), Karlsruher Institut für Technologie (KIT)


As competition in the biopharmaceutical market gets keener due to the market entry of biosimilars, process analytical technologies (PATs) play an important role for process automation and cost reduction. This article will give a general overview and address the recent innovations and applications of spectroscopic methods as PAT tools in the downstream processing of biologics. As data analysis strategies are a crucial part of PAT, the review discusses frequently used data analysis techniques and addresses data fusion methodologies as the combination of several sensors is moving forward in the field. The last chapter will give an outlook on the application of spectroscopic methods in combination with chemometrics and model predictive control (MPC) for downstream processes.

Verlagsausgabe §
DOI: 10.5445/IR/1000118022
Veröffentlicht am 28.08.2020
DOI: 10.1007/s00216-020-02407-z
Zitationen: 33
Web of Science
Zitationen: 26
Zitationen: 37
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2020
Sprache Englisch
Identifikator ISSN: 0016-1152, 0372-7920, 0937-0633, 1432-1130, 1618-2642, 1618-2650
KITopen-ID: 1000118022
Erschienen in Analytical and bioanalytical chemistry
Verlag Springer Verlag
Band 412
Heft 9
Seiten 2047–2064
Vorab online veröffentlicht am 07.03.2020
Schlagwörter Process analytical technology, Spectroscopy, Chemometrics, Downstream processing, Biologics
Nachgewiesen in Dimensions
Web of Science
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